dopamine key to mystery of metabolic dysfunction & anti-psychotic drugs

Anti-psychotic drugs do not only block dopamine signaling in the brain, they also block dopamine signaling in the pancreas. Blocking dopamine signaling in the pancreas leads to uncontrolled production of blood-glucose regulating hormones, increasing obesity and diabetes risks. Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and …

vagus nerve: brain-gut axis in psychiatric and inflammatory disorders – part II

The vagus nerve is a modulator of intestinal immune homeostasis. The gastrointestinal tract is constantly confronted with food antigens, possible pathogens, and symbiotic intestinal microbiota that present a risk factor for intestinal inflammation (63). It is highly innervated by vagal fibers that connect the CNS with the intestinal immune system, making vagus a major component, …